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ea0035p738 | Nuclear receptors and signal transduction | ECE2014

Thyroid receptors antagonizes TGFβ actions in vivo and in culture cells

Merino Elvira Alonso , Martin Orozco Rosa M , Llorente Lidia Ruiz , Fanjul Rodriguez Luisa Fernanda , Martinez-Iglesias Olaia , Velasco-Martin Juan Pedro , Regadera Javier , Aranda Ana

Transforming growth factor beta (TGFβ), which plays a key role in cancer and fibrotic disorders, mediates its actions mainly through activation of Smad transcription factors, which bind to Smad Binding Elements (SBEs) in target genes. We have previously observed that the thyroid hormone T3 blocks transactivation of SBE-containing reporter plasmids by TGFβ, and represses transcription of endogenous TGFβ target genes. We have now analysed the thyroid ho...

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ea0032p722 | Nuclear receptors and signal transduction | ECE2013

The thyroid hormone receptors inhibit invasive and fibrotic responses to TGFβ by transcriptional cross-talk with smad-transcription factors

Alonso-Merino Elvira , Martin-Orozco Rosa M , Ruiz-Llorente Lidia , Fanjul-Rodriguez Luisa Fernanda , Martinez-Igesias Olaia , Velasco-Martin Juan Pedro , Regadera Javier , Aranda Ana

Transforming growth factor β (TGFβ) signals through activation of Smad transcription factors, which bind to Smad binding elements (SBEs) in target genes. TGFβ can promote cancer cell proliferation and invasion, and plays a key role in the pathogenesis of scleroderma and other fibrotic disorders. We have previously shown that the thyroid hormone receptors (TRs) can block tumor growth and invasion. We now have analyzed the possibility that TRs could antagonize TGF...

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Endocrine Abstracts

Thyroid receptors antagonizes TGFβ actions in vivo and in culture cells

The thyroid hormone receptors inhibit invasive and fibrotic responses to TGFβ by transcriptional cross-talk with smad-transcription factors

BiosciAbstracts